The impact of Mendelian sleep and circadian genetic variants in a population setting.

The impact of Mendelian sleep and circadian genetic variants in a population setting.

Rare variants in ten genes have been reported to cause Mendelian sleep conditions characterised by extreme sleep duration or timing. These include familial natural short sleep (ADRB1, DEC2/BHLHE41, GRM1 and NPSR1), advanced sleep phase (PER2, PER3, CRY2, CSNK1D and TIMELESS) and delayed sleep phase...

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Main Authors: Michael N Weedon, Samuel E Jones, Jacqueline M Lane, Jiwon Lee, Hanna M Ollila, Amy Dawes, Jess Tyrrell, Robin N Beaumont, Timo Partonen, Ilona Merikanto, Stephen S Rich, Jerome I Rotter, Timothy M Frayling, Martin K Rutter, Susan Redline, Tamar Sofer, Richa Saxena, Andrew R Wood
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-09-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010356&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010356&type=printable

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