A multidisciplinary analysis of over 53,000 fascioliasis patients along the 1995–2019 countrywide spread in Vietnam defines a new epidemiological baseline for One Health approaches
Fascioliasis, only foodborne trematodiasis of worldwide distribution, is caused by Fasciola hepatica and F. gigantica, liver flukes transmitted by freshwater snails. Southern and southeastern Asia is an emerging hot spot of F. gigantica, despite its hitherto less involvement in human infection. In V...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | One Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352771424001952 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849220164296376320 |
|---|---|
| author | Nguyen Van De Pham Ngoc Minh Thanh Hoa Le Do Trung Dung Tran Thanh Duong Bui Van Tuan Le Thanh Dong Nguyen Van Vinh Chau Pablo F. Cuervo M. Dolores Bargues M. Adela Valero Albis Francesco Gabrielli Antonio Montresor Santiago Mas-Coma |
| author_facet | Nguyen Van De Pham Ngoc Minh Thanh Hoa Le Do Trung Dung Tran Thanh Duong Bui Van Tuan Le Thanh Dong Nguyen Van Vinh Chau Pablo F. Cuervo M. Dolores Bargues M. Adela Valero Albis Francesco Gabrielli Antonio Montresor Santiago Mas-Coma |
| author_sort | Nguyen Van De |
| collection | DOAJ |
| description | Fascioliasis, only foodborne trematodiasis of worldwide distribution, is caused by Fasciola hepatica and F. gigantica, liver flukes transmitted by freshwater snails. Southern and southeastern Asia is an emerging hot spot of F. gigantica, despite its hitherto less involvement in human infection. In Vietnam, increasing cases have been reported since 1995, whereas only sixteen throughout 1800–1994. A database was created to include epidemiological data of fascioliasis patients from the 63 Vietnam provinces throughout 1995–2019. Case profiles were based on serology, symptoms, eosinophilia, imaging techniques, stool egg finding, and post-specific-treatment recovery. Radio broadcasting about symptoms and costless diagnosis/treatment led patients to hospitals after symptom onset. Yearly case numbers were modelled and spatio-temporally analyzed. Missing data and confounders were assessed. The countrywide spread has no precedent. It started in the central coast, including 53,109 patients, mostly adults and females. Seasonality, linked to vegetable consumption, peaks in June, although the intensity of this peak differs according to relief/climatic zones. Incidence data and logistic regression curves are obtained for the first time in human fascioliasis. Fasciolid hybrids accompanying the spreading F. gigantica flukes, and climate change assessed by risk index correlations, are both ruled out as outbreak causes. Human-guided movements of livestock from an original area prove to be the way used by fasciolids and lymnaeid vectors to expand geographically. Radix viridis, a highly efficient transmitting and colonizing vector, played a decisive role in the spread. The use of irrigated crop fields, widely inhabited by R. viridis, for livestock grazing facilitated the transmission and spread of the disease. General physician awareness and diagnostic capacity improvement proved the successful impact of such knowledge transfer in facilitating and increasing patient infection detection. Information, education and communication to the public by radio broadcasting demonstrated to be very helpful. Fasciola gigantica is able to cause epidemic and endemic situations similar to F. hepatica. The magnitude of the human outbreak in Vietnam is a health wake-up call for southern and southeastern countries of Asia which present the highest human population densities with increasing food demands, uncontrolled livestock inter-country exchange, foreign import practices, and monsoon's increasing climate change impact. |
| format | Article |
| id | doaj-art-89f3bf8fc428432dbd4af899bb8bff6f |
| institution | Kabale University |
| issn | 2352-7714 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | One Health |
| spelling | doaj-art-89f3bf8fc428432dbd4af899bb8bff6f2024-12-18T08:49:21ZengElsevierOne Health2352-77142024-12-0119100869A multidisciplinary analysis of over 53,000 fascioliasis patients along the 1995–2019 countrywide spread in Vietnam defines a new epidemiological baseline for One Health approachesNguyen Van De0Pham Ngoc Minh1Thanh Hoa Le2Do Trung Dung3Tran Thanh Duong4Bui Van Tuan5Le Thanh Dong6Nguyen Van Vinh Chau7Pablo F. Cuervo8M. Dolores Bargues9M. Adela Valero10Albis Francesco Gabrielli11Antonio Montresor12Santiago Mas-Coma13Ha Noi Medical University, 01 Ton That Tung, Ha Noi, Viet NamHa Noi Medical University, 01 Ton That Tung, Ha Noi, Viet NamInstitute of Biotechnology, 18 Hoang Quoc Viet, Ha Noi, Viet NamNational Institute of Malariology, Parasitology and Entomology, Ha Noi, Viet NamNational Institute of Malariology, Parasitology and Entomology, Ha Noi, Viet NamQuy Nhon Institute of Malariology, Parasitology and Entomology, Quy Nhon, Viet NamHo Chi Minh Institute of Malariology, Parasitology and Entomology, Ho Chi Minh, Viet NamHo Chi Minh Hospital of Tropical Diseases, Ho Chi Minh City, Viet NamDepartamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Av. Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11. Planta 0, 28029 Madrid, SpainDepartamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Av. Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11. Planta 0, 28029 Madrid, SpainDepartamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Av. Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11. Planta 0, 28029 Madrid, SpainGlobal Neglected Tropical Diseases Programme (NTD), World Health Organization, Avenue Appia 20, CH-1211 Geneva 27, SwitzerlandGlobal Neglected Tropical Diseases Programme (NTD), World Health Organization, Avenue Appia 20, CH-1211 Geneva 27, SwitzerlandDepartamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Av. Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11. Planta 0, 28029 Madrid, Spain; Corresponding author at: Departamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Av. Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.Fascioliasis, only foodborne trematodiasis of worldwide distribution, is caused by Fasciola hepatica and F. gigantica, liver flukes transmitted by freshwater snails. Southern and southeastern Asia is an emerging hot spot of F. gigantica, despite its hitherto less involvement in human infection. In Vietnam, increasing cases have been reported since 1995, whereas only sixteen throughout 1800–1994. A database was created to include epidemiological data of fascioliasis patients from the 63 Vietnam provinces throughout 1995–2019. Case profiles were based on serology, symptoms, eosinophilia, imaging techniques, stool egg finding, and post-specific-treatment recovery. Radio broadcasting about symptoms and costless diagnosis/treatment led patients to hospitals after symptom onset. Yearly case numbers were modelled and spatio-temporally analyzed. Missing data and confounders were assessed. The countrywide spread has no precedent. It started in the central coast, including 53,109 patients, mostly adults and females. Seasonality, linked to vegetable consumption, peaks in June, although the intensity of this peak differs according to relief/climatic zones. Incidence data and logistic regression curves are obtained for the first time in human fascioliasis. Fasciolid hybrids accompanying the spreading F. gigantica flukes, and climate change assessed by risk index correlations, are both ruled out as outbreak causes. Human-guided movements of livestock from an original area prove to be the way used by fasciolids and lymnaeid vectors to expand geographically. Radix viridis, a highly efficient transmitting and colonizing vector, played a decisive role in the spread. The use of irrigated crop fields, widely inhabited by R. viridis, for livestock grazing facilitated the transmission and spread of the disease. General physician awareness and diagnostic capacity improvement proved the successful impact of such knowledge transfer in facilitating and increasing patient infection detection. Information, education and communication to the public by radio broadcasting demonstrated to be very helpful. Fasciola gigantica is able to cause epidemic and endemic situations similar to F. hepatica. The magnitude of the human outbreak in Vietnam is a health wake-up call for southern and southeastern countries of Asia which present the highest human population densities with increasing food demands, uncontrolled livestock inter-country exchange, foreign import practices, and monsoon's increasing climate change impact.http://www.sciencedirect.com/science/article/pii/S2352771424001952Human fascioliasisFasciola giganticaFasciola hybridsGeographically spreading outbreakCase number analysesSpatio-temporal clustering |
| spellingShingle | Nguyen Van De Pham Ngoc Minh Thanh Hoa Le Do Trung Dung Tran Thanh Duong Bui Van Tuan Le Thanh Dong Nguyen Van Vinh Chau Pablo F. Cuervo M. Dolores Bargues M. Adela Valero Albis Francesco Gabrielli Antonio Montresor Santiago Mas-Coma A multidisciplinary analysis of over 53,000 fascioliasis patients along the 1995–2019 countrywide spread in Vietnam defines a new epidemiological baseline for One Health approaches One Health Human fascioliasis Fasciola gigantica Fasciola hybrids Geographically spreading outbreak Case number analyses Spatio-temporal clustering |
| title | A multidisciplinary analysis of over 53,000 fascioliasis patients along the 1995–2019 countrywide spread in Vietnam defines a new epidemiological baseline for One Health approaches |
| title_full | A multidisciplinary analysis of over 53,000 fascioliasis patients along the 1995–2019 countrywide spread in Vietnam defines a new epidemiological baseline for One Health approaches |
| title_fullStr | A multidisciplinary analysis of over 53,000 fascioliasis patients along the 1995–2019 countrywide spread in Vietnam defines a new epidemiological baseline for One Health approaches |
| title_full_unstemmed | A multidisciplinary analysis of over 53,000 fascioliasis patients along the 1995–2019 countrywide spread in Vietnam defines a new epidemiological baseline for One Health approaches |
| title_short | A multidisciplinary analysis of over 53,000 fascioliasis patients along the 1995–2019 countrywide spread in Vietnam defines a new epidemiological baseline for One Health approaches |
| title_sort | multidisciplinary analysis of over 53 000 fascioliasis patients along the 1995 2019 countrywide spread in vietnam defines a new epidemiological baseline for one health approaches |
| topic | Human fascioliasis Fasciola gigantica Fasciola hybrids Geographically spreading outbreak Case number analyses Spatio-temporal clustering |
| url | http://www.sciencedirect.com/science/article/pii/S2352771424001952 |
| work_keys_str_mv | AT nguyenvande amultidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT phamngocminh amultidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT thanhhoale amultidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT dotrungdung amultidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT tranthanhduong amultidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT buivantuan amultidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT lethanhdong amultidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT nguyenvanvinhchau amultidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT pablofcuervo amultidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT mdoloresbargues amultidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT madelavalero amultidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT albisfrancescogabrielli amultidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT antoniomontresor amultidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT santiagomascoma amultidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT nguyenvande multidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT phamngocminh multidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT thanhhoale multidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT dotrungdung multidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT tranthanhduong multidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT buivantuan multidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT lethanhdong multidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT nguyenvanvinhchau multidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT pablofcuervo multidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT mdoloresbargues multidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT madelavalero multidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT albisfrancescogabrielli multidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT antoniomontresor multidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches AT santiagomascoma multidisciplinaryanalysisofover53000fascioliasispatientsalongthe19952019countrywidespreadinvietnamdefinesanewepidemiologicalbaselineforonehealthapproaches |