Nose-to-brain delivery of human muse cells enhances structural and functional recovery in the murine ischemic stroke model

Abstract Muse cells are endogenous, non-tumorigenic, pluripotent-like stem cells already applied to clinical trials based on intravenous injection. They can selectively home to the post-infarct area, replenish apoptotic neural cells by phagocytosis-induced differentiation, and enhance functional rec...

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Bibliographic Details
Main Authors: Shusuke Yamamoto, Keitaro Shiraishi, Yoshihiro Kushida, Yo Oguma, Shohei Wakao, Mari Dezawa, Satoshi Kuroda
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-96451-3
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