Effects of tianeptine on mTORC1-mediated neuronal autophagy in primary rat hippocampal neurons under nutrient deprivation

Abstract The aim of this study was to investigate the effects of the antidepressant tianeptine on the mechanistic target of rapamycin complex 1(mTORC1)-mediated autophagy pathway in primary hippocampal neurons exposed to B27-deprived conditions. When primary hippocampal neurons were treated with tia...

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Bibliographic Details
Main Authors: Mi Kyoung Seo, Hyewon Kim, Ah Jeong Choi, Dae-Hyun Seog, Weon-Gyu Kho, Sung Woo Park, Jung Goo Lee
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-025-92988-5
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