Aberrant fragmentomic features of circulating cell-free mitochondrial DNA as novel biomarkers for multi-cancer detection

Aberrant fragmentomic features of circulating cell-free mitochondrial DNA as novel biomarkers for multi-cancer detection

Abstract Fragmentomic features of circulating cell free mitochondrial DNA (ccf-mtDNA) including fragmentation profile, 5’ end base preference and motif diversity are poorly understood. Here, we generated ccf-mtDNA sequencing data of 1607 plasma samples using capture-based next generation sequencing....

Full description

Saved in:
Bibliographic Details
Main Authors: Yang Liu, Fan Peng, Siyuan Wang, Huanmin Jiao, Miao Dang, Kaixiang Zhou, Wenjie Guo, Shanshan Guo, Huanqin Zhang, Wenjie Song, Jinliang Xing
Format: Article
Language:English
Published: Springer Nature 2024-10-01
Series:EMBO Molecular Medicine
Subjects:
Fragmentomics
Circulating Cell-Free Mitochondrial DNA
Multi-Cancer Detection
Tissue-of-Origin Classification
Biomarker
Online Access:https://doi.org/10.1038/s44321-024-00163-6
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s44321-024-00163-6

Similar Items