LIN28 upregulation in primary human T cells impaired CAR T antitumoral activity

LIN28 upregulation in primary human T cells impaired CAR T antitumoral activity

LIN28, a highly conserved RNA-binding protein that acts as a posttranscriptional modulator, plays a vital role in the regulation of T-cell development, reprogramming, and immune activity in infectious diseases and T-cell-based immunotherapies. LIN28 inhibit the expression of let-7 miRNAs, the most p...

Full description

Saved in:
Bibliographic Details
Main Authors: Patricia Garcia-Rodriguez, Laura Hidalgo, Miguel Angel Rodriguez-Milla, Beatriz Somovilla-Crespo, Javier Garcia-Castro
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Immunology
Subjects:
LIN28
let-7
CAR T
immunotherapy
osteosarcoma
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1462796/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1462796/full

Similar Items