Integrating single-cell RNA sequencing and spatial transcriptomics reveals the therapeutic effect of nitazoxanide in head and neck squamous cell carcinoma

Integrating single-cell RNA sequencing and spatial transcriptomics reveals the therapeutic effect of nitazoxanide in head and neck squamous cell carcinoma

Abstract Background Head and Neck Squamous Cell Carcinoma (HNSCC) is a prevalent and deadly cancer with limited treatment options, for which autophagy has a dual impact. Nitazoxanide is a broad-spectrum antiviral drug showing promise in treating cancer, but its role in regulating autophagy in HNSCC...

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Bibliographic Details
Main Authors: Xiaohua Jiang, Liqi Chen, Zixia Xu, Hangzhe Sun, Jing Ye, Ziyi Guo, Mang Xiao
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Discover Oncology
Subjects:
Head and neck squamous cell carcinoma
Nitazoxanide
Autophagy
Network pharmacology
Bioinformatics
Online Access:https://doi.org/10.1007/s12672-025-03372-8
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https://doi.org/10.1007/s12672-025-03372-8

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