DNA-demethylation by DAC induces MAGE expression and MAGE-specific T cell reactivity against tumors but also healthy cell subsets

DNA-demethylation by DAC induces MAGE expression and MAGE-specific T cell reactivity against tumors but also healthy cell subsets

Cancer testis antigens (CTAs) can be expressed in tumors, whereas expression is silenced in normal tissue except for the immune-privileged testis. This quasi-tumor-restricted expression makes CTAs attractive targets for T cell receptor (TCR) gene therapy. However, CTA-specific TCR gene therapy is on...

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Main Authors: Marije A.J. de Rooij, Miranda H. Meeuwsen, Anne K. Wouters, Dennis F.G. Remst, Renate S. Hagedoorn, Dirk M. van der Steen, Els M.E. Verdegaal, Tassilo L.A. Wachsmann, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
CD8+ T cell
TCR
DAC
MAGE
DNA-demethylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329925000876
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