Proteomic discovery analysis of quantitatively assessed emphysema in the general population. The MESA Lung Study

Proteomic discovery analysis of quantitatively assessed emphysema in the general population. The MESA Lung Study

Abstract Background Pulmonary emphysema occurs frequently in older adults, often without airflow limitation. Its presence predicts symptoms, respiratory hospitalizations and deaths, and all-cause mortality. Proteomics may provide further insights into emphysema pathogenesis and inform therapeutic ta...

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Main Authors: Daniel E. Guzman, Lisa Ruvuna, Claire J. Guo, Yifei Sun, Katherine A. Pratte, Ani W. Manichaikul, John S. Kim, Wendy S. Post, Alain G. Bertoni, Norrina B. Allen, Karol E. Watson, James S. Pankow, Eric A. Hoffman, Ruth F. Dubin, Rajat Deo, Igor Z. Barjaktarevic, Eugene R. Bleecker, Christopher B. Cooper, Victor E. Ortega, Annette T. Hastie, Robert Paine, James Michael Wells, Jeffrey L. Curtis, Edwin K. Silverman, Prescott G. Woodruff, Christine Kim Garcia, Jerome I. Rotter, Russell P. Bowler, Peter Ganz, R. Graham Barr
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Respiratory Research
Subjects:
Proteomics
Biomarkers
Emphysema
Online Access:https://doi.org/10.1186/s12931-025-03312-8
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https://doi.org/10.1186/s12931-025-03312-8

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