TDO2 inhibition counters Benzo[a]pyrene-induced immune evasion and suppresses tumorigenesis in lung adenocarcinoma

TDO2 inhibition counters Benzo[a]pyrene-induced immune evasion and suppresses tumorigenesis in lung adenocarcinoma

Abstract Introduction Benzo[a]pyrene (BaP) is a toxic polycyclic aromatic hydrocarbon known as an exogenous AhR ligand. This study investigates the role of BaP in inducing immune checkpoint expression in lung adenocarcinoma (LUAD) and the underlying mechanisms involving the aryl hydrocarbon receptor...

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Bibliographic Details
Main Authors: İsa Taş, Mücahit Varlı, Sultan Pulat, Hyun Bo Sim, Jong-Jin Kim, Hangun Kim
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cancer & Metabolism
Subjects:
Benzo[a]pyrene
TDO2
ICOSL
PD-L1
AhR
Immune evasion
Online Access:https://doi.org/10.1186/s40170-024-00365-z
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https://doi.org/10.1186/s40170-024-00365-z

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