Protein-mediated stabilization of amphotericin B increases its efficacy against diverse fungal pathogens

Protein-mediated stabilization of amphotericin B increases its efficacy against diverse fungal pathogens

ABSTRACT Amphotericin B (AMB), a potent and broad-spectrum antifungal agent, faces solubility and toxicity challenges in clinical use. In this study, we explored the ability of DewY and EASΔ15, class I fungal hydrophobin proteins with unique amphipathic properties and self-assembly capabilities, to...

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Bibliographic Details
Main Authors: Kenya E. Fernandes, Caitlin L. Johnston, Brayden C. Williams, Dee A. Carter, Margaret Sunde
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:Microbiology Spectrum
Subjects:
amphotericin B
hydrophobins
antifungals
combination therapy
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00686-25
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https://journals.asm.org/doi/10.1128/spectrum.00686-25

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