Circulating tumor DNA fraction predicts residual cancer burden post-neoadjuvant chemotherapy in triple negative breast cancer

Circulating tumor DNA fraction predicts residual cancer burden post-neoadjuvant chemotherapy in triple negative breast cancer

Purpose: Pathologic response after preoperative/neoadjuvant chemotherapy (NAC) is a continuum that can range from complete pathologic response (pCR) to extensive residual disease (RD). We hypothesized that post-NAC plasma circulating tumor DNA (ctDNA) fraction (TF) reflect pathologic response as con...

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Bibliographic Details
Main Authors: Naing Lin Shan, Billie Gould, Xiaohong Wang, Giancarlo Bonora, Kim Blenman, Julia Foldi, Gerson Espinoza Campos, Myles Walsh, Pan Du, Lajos Pusztai
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:The Journal of Liquid Biopsy
Subjects:
Minimal residual disease (MRD)
Circulating tumor DNA (ctDNA)
Residual cancer burden (RCB)
Online Access:http://www.sciencedirect.com/science/article/pii/S295019542400033X
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