PDK2-enhanced glycolysis aggravates fibrosis via IL11 signaling pathway in Graves’ orbitopathy

PDK2-enhanced glycolysis aggravates fibrosis via IL11 signaling pathway in Graves’ orbitopathy

ObjectivesTransforming growth factor β1 (TGFβ1)-interleukin 11 (IL11) is a newly found critical signaling pathway in fibrotic diseases such as Graves’ orbitopathy (GO). It has now been confirmed that enhanced glycolysis plays a key role in the pathogenesis of GO. However, little is known about the r...

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Bibliographic Details
Main Authors: Zhiyu Peng, Rui Huang, Lu Gan, Jinghan Wang, Xiaofeng Li, Jie Ding, Yinan Han, Jihong Wu, Kang Xue, Jie Guo, Rui Zhang, Jiang Qian, Ruiqi Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
glycolysis
interleukin-11
transforming growth factor β1
orbital fibroblast
Graves’ orbitopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1537365/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1537365/full

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