DISTRIBUTION PATTERNS OF ALLELES AND GENOTYPES FOR HLA-G 3'UTR 14-bp ins/del IN MOTHERS OF CHILDREN WITH CONGENITAL HEART DEFECTS OR REPRODUCTIVE LOSSES AT EARLY GESTATION TERMS

DISTRIBUTION PATTERNS OF ALLELES AND GENOTYPES FOR HLA-G 3'UTR 14-bp ins/del IN MOTHERS OF CHILDREN WITH CONGENITAL HEART DEFECTS OR REPRODUCTIVE LOSSES AT EARLY GESTATION TERMS

HLA-G is the main molecule through which provides tolerance of maternal immune microenvironment to the semi-allogeneic embryo. Polymorphic variant of 14-bp ins/del in the HLA-G 3’UTR gene affects stability and expression of specific mRNA and, thereby, efficiency of immune rejection blockade of the s...

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Bibliographic Details
Main Authors: A. V. Shabaldin, A. V. Tsepokina, S. A. Shmulevich, A. V. Ponasenko, P. M. Kryukov, E. V. Shabaldina
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2017-12-01
Series:Медицинская иммунология
Subjects:
hla-g 3’utr 14-bp ins/del
gestation
reproductive loss
congenital heart diseases
Online Access:https://www.mimmun.ru/mimmun/article/view/1400
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https://www.mimmun.ru/mimmun/article/view/1400

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