Three-dimensional genomic characterization of two multiple myeloma patients with normal karyotype and complex karyotype

Three-dimensional genomic characterization of two multiple myeloma patients with normal karyotype and complex karyotype

[Objective] To investigate the functional differences and potential effects of chromatin spatial structure in patients with normal karyotype and complex karyotype multiple myeloma. [Methods] High-throughput chromosome conformational capture (Hi-C) analysis was performed on plasma cells of 1 case wit...

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Bibliographic Details
Main Authors: WANG Yue, CHEN Mengsi, CHEN Ming, LI Yanju, GUAN Xiaohong, LEI Lihua, TAO Li, LIU Xiaoxiao, HE Dong, FEI Xiaoli, ZHANG Kaiji
Format: Article
Language:zho
Published: Institute of Blood Transfusion of Chinese Academy of Medical Sciences 2024-11-01
Series:Zhongguo shuxue zazhi
Subjects:
multiple myeloma
plasma cells
chromatin spatial structure
gene expression regulation
Online Access:https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2024.11.006&lang=en
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https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2024.11.006&lang=en

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