Flagellar motility and the mucus environment influence aggregation-mediated antibiotic tolerance of Pseudomonas aeruginosa in chronic lung infection

Flagellar motility and the mucus environment influence aggregation-mediated antibiotic tolerance of Pseudomonas aeruginosa in chronic lung infection

ABSTRACT Pseudomonas aeruginosa routinely causes chronic lung infection in individuals with muco-obstructive airway diseases (MADs). In MADs, P. aeruginosa forms antibiotic-tolerant biofilm-like aggregates within hyperconcentrated airway mucus. While the contribution of mucin hyper-concentration to...

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Bibliographic Details
Main Authors: Matthew G. Higgs, Matthew A. Greenwald, Cristian Roca, Jade K. Macdonald, Ashelyn E. Sidders, Brian P. Conlon, Matthew C. Wolfgang
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mBio
Subjects:
Pseudomonas aeruginosa
flagellar motility
aggregation
antibiotic efficacy
muco-obstructive airway diseases
Online Access:https://journals.asm.org/doi/10.1128/mbio.00831-25
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https://journals.asm.org/doi/10.1128/mbio.00831-25

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