The Secretome of Brain Endothelial Cells Exposed to the Pyrrolizidine Alkaloid Monocrotaline Induces Astrocyte Reactivity and Is Neurotoxic

The Secretome of Brain Endothelial Cells Exposed to the Pyrrolizidine Alkaloid Monocrotaline Induces Astrocyte Reactivity and Is Neurotoxic

Monocrotaline (MCT) has well-characterized hepatotoxic and pneumotoxic effects attributed to its active pyrrole metabolites. Studies have previously shown that astrocytes and neurons are targets of MCT, and that toxicity is attributed to astrocyte P450 metabolism to reactive metabolites. However, li...

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Main Authors: Letícia Oliveira Santos, Julita Maria Pereira Borges, Juliana Lago Leite, Mauricio Moraes Victor, Adriana Lopes da Silva, Cleonice Creusa dos Santos, Victor Diógenes Amaral da Silva, Ravena Pereira do Nascimento, Silvia Lima Costa
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Toxins
Subjects:
monocrotaline
neurotoxicity
blood–brain barrier
brain endothelial cells
astrocytes
Online Access:https://www.mdpi.com/2072-6651/17/2/65
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