Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations

Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations

Abstract Background Genome-wide association studies (GWAS) have identified hundreds of loci underlying adult-onset asthma (AOA) and childhood-onset asthma (COA). However, the causal variants, regulatory elements, and effector genes at these loci are largely unknown. Methods We performed heritability...

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Main Authors: Xiaoyuan Zhong, Robert Mitchell, Christine Billstrand, Emma E. Thompson, Noboru J. Sakabe, Ivy Aneas, Isabella M. Salamone, Jing Gu, Anne I. Sperling, Nathan Schoettler, Marcelo A. Nóbrega, Xin He, Carole Ober
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Genome Medicine
Subjects:
Asthma genetics
Genome-wide association studies
Fine-mapping
Functional annotations
Epigenomics
Cis-regulatory elements
Online Access:https://doi.org/10.1186/s13073-025-01459-z
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https://doi.org/10.1186/s13073-025-01459-z

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