Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1.

Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1.

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder resulting in large kidney cysts and eventual kidney failure. Mutations in either the PKD1 or PKD2/TRPP2 genes and their respective protein products, polycystin-1 (PC1) and polycystin-2 (PC2) result in ADPKD. PC2 is known to f...

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Main Authors: Owen M Woodward, Yun Li, Shengqiang Yu, Patrick Greenwell, Claas Wodarczyk, Alessandra Boletta, William B Guggino, Feng Qian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0012305&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0012305&type=printable

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