Does Thrombocyte Size Give Us an Idea about Thrombocytosis Etiology?
In the presence of a pathogenetic mutation in JAK2 or MPL, a differential diagnosis of essential thrombocythemia (ET) from reactive causes is relatively simple. However, in patients with suspected ET who lack JAK2 and MPL mutations, the exclusion of secondary causes is especially important. The stud...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/598653 |
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| author | Selami Kocak Toprak Betul Erismis Sema Karakus Nazmiye Kursun Aysegul Haberal Mustafa Gurhan Ulusoy |
| author_facet | Selami Kocak Toprak Betul Erismis Sema Karakus Nazmiye Kursun Aysegul Haberal Mustafa Gurhan Ulusoy |
| author_sort | Selami Kocak Toprak |
| collection | DOAJ |
| description | In the presence of a pathogenetic mutation in JAK2 or MPL, a differential diagnosis of essential thrombocythemia (ET) from reactive causes is relatively simple. However, in patients with suspected ET who lack JAK2 and MPL mutations, the exclusion of secondary causes is especially important. The study was aimed to explore the clinical application of particularly mean platelet volume (MPV), hemoglobin, red blood cell indices, white blood cell, serum iron profile, and C-reactive protein level in the differential diagnosis of thrombocytosis. Medical records of 49 patients, consisting of reactive thrombocytosis (RT) and ET were retrospectively reviewed. The mean MPV level in RT group was 7.49 fL, and in ET group was 8.80 fL (P<0.01). A cutoff point of <8.33 fL was found to have significant predictive value according to ROC curve analysis. This cutoff was associated with 83% positive predictive value (PPV) and 74% negative predictive value (NPV) in the diagnosis of ET and had a sensitivity of 65% and specificity of 89% for ET. Investigation of MPV is cheap, quick, and noninvasive, and may serve as a predictor of primary thrombocytosis. High sensitivity, specificity, PPV, and NPV enable this test an important tool and a possible surrogate marker in clinical practice. |
| format | Article |
| id | doaj-art-88d9636dcec14a77adb046f84c44f7f8 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-88d9636dcec14a77adb046f84c44f7f82025-02-03T05:52:09ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/598653598653Does Thrombocyte Size Give Us an Idea about Thrombocytosis Etiology?Selami Kocak Toprak0Betul Erismis1Sema Karakus2Nazmiye Kursun3Aysegul Haberal4Mustafa Gurhan Ulusoy5Department of Hematology, Faculty of Medicine, Baskent University, 06490 Ankara, TurkeyDepartment of Hematology, Faculty of Medicine, Baskent University, 06490 Ankara, TurkeyDepartment of Hematology, Faculty of Medicine, Baskent University, 06490 Ankara, TurkeyDepartment of Biostatistics, Faculty of Medicine, Ankara University, 06100 Ankara, TurkeyHematology Laboratory, Faculty of Medicine, Baskent University, 06490 Ankara, TurkeyDepartment of Plastic, Reconstructive and Aesthetic Surgery, Ankara Training and Research Hospital, 06080 Ankara, TurkeyIn the presence of a pathogenetic mutation in JAK2 or MPL, a differential diagnosis of essential thrombocythemia (ET) from reactive causes is relatively simple. However, in patients with suspected ET who lack JAK2 and MPL mutations, the exclusion of secondary causes is especially important. The study was aimed to explore the clinical application of particularly mean platelet volume (MPV), hemoglobin, red blood cell indices, white blood cell, serum iron profile, and C-reactive protein level in the differential diagnosis of thrombocytosis. Medical records of 49 patients, consisting of reactive thrombocytosis (RT) and ET were retrospectively reviewed. The mean MPV level in RT group was 7.49 fL, and in ET group was 8.80 fL (P<0.01). A cutoff point of <8.33 fL was found to have significant predictive value according to ROC curve analysis. This cutoff was associated with 83% positive predictive value (PPV) and 74% negative predictive value (NPV) in the diagnosis of ET and had a sensitivity of 65% and specificity of 89% for ET. Investigation of MPV is cheap, quick, and noninvasive, and may serve as a predictor of primary thrombocytosis. High sensitivity, specificity, PPV, and NPV enable this test an important tool and a possible surrogate marker in clinical practice.http://dx.doi.org/10.1100/2012/598653 |
| spellingShingle | Selami Kocak Toprak Betul Erismis Sema Karakus Nazmiye Kursun Aysegul Haberal Mustafa Gurhan Ulusoy Does Thrombocyte Size Give Us an Idea about Thrombocytosis Etiology? The Scientific World Journal |
| title | Does Thrombocyte Size Give Us an Idea about Thrombocytosis Etiology? |
| title_full | Does Thrombocyte Size Give Us an Idea about Thrombocytosis Etiology? |
| title_fullStr | Does Thrombocyte Size Give Us an Idea about Thrombocytosis Etiology? |
| title_full_unstemmed | Does Thrombocyte Size Give Us an Idea about Thrombocytosis Etiology? |
| title_short | Does Thrombocyte Size Give Us an Idea about Thrombocytosis Etiology? |
| title_sort | does thrombocyte size give us an idea about thrombocytosis etiology |
| url | http://dx.doi.org/10.1100/2012/598653 |
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