Radiation suppresses liver metastases via exosome secretion in pancreatic cancer cells

Radiation suppresses liver metastases via exosome secretion in pancreatic cancer cells

Abstract Pancreatic cancer (PC) is difficult to treat because of its radio-resistance and metastases. Radiotherapy modifies the tumor microenvironment (TME) and affects PC progression. Exosomes are produced in response to radiation, but their nature and mechanisms of action are unclear. We investiga...

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Bibliographic Details
Main Authors: Ai Nakaoka, Mohammed Salah, Zhangzhu Ruixian, Makiko Nakahana, Yasuyuki Shimizu, Qin Qin, Qu Zhang, Naritoshi Mukumoto, Kana Kobayashi, Yukihiro Ikegaki, Hiroaki Akasaka, Sachiko Inubushi, Yu-ichiro Koma, Takeaki Ishihara, Daisuke Miyawaki, Takashi Sasayama, Ryohei Sasaki
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Exosomes
Liver metastasis
MiR-3160-5p
Pancreatic cancer
Radiation therapy
RGMB
Online Access:https://doi.org/10.1038/s41598-025-08826-1
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https://doi.org/10.1038/s41598-025-08826-1

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