Exploring the potential anti-apoptotic effects of traditional Chinese medicine in intervertebral disc degeneration: mechanisms and therapeutic prospects

Exploring the potential anti-apoptotic effects of traditional Chinese medicine in intervertebral disc degeneration: mechanisms and therapeutic prospects

Intervertebral disc degeneration (IDD) stands as one of the primary culprits behind low back pain and disability, imposing substantial burdens on individual health, families, and societal wellbeing. The multifactorial etiology and complex pathology of IDD pose significant challenges, with molecular...

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Bibliographic Details
Main Authors: Kuaixiang Zhang, Lei Wan, Malik Ihsan Ullah Khan, Feifei Pu, Man Liu, Zhiqiang Zhao, Jitian Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Physiology
Subjects:
intervertebral disc degeneration
apoptosis
death receptor pathway
mitochondrial pathway
endoplasmic reticulum stress pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1617215/full
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https://www.frontiersin.org/articles/10.3389/fphys.2025.1617215/full

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