Wheels turning: CHO cell modeling moves into a digital biomanufacturing era

Wheels turning: CHO cell modeling moves into a digital biomanufacturing era

Recent advancements in biologics production using CHO cells have been partly driven by improved understanding of how variations in the cell culture environment influence cellular metabolism, productivity, and the attributes of the final product. In-silico models serve a valuable role in mapping the...

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Bibliographic Details
Main Authors: Sandeep Ranpura, Vishwanathgouda Maralingannavar, Alexandra-Gabriela Gheorghe, Edward Ma, James Morrissey, Michael J. Betenbaugh, Deniz Demirhan
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Mechanistic modeling
Machine learning
Hybrid model
Biomanufacturing
Omics
CHO metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S200103702500251X
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