Single-cell sequencing unveils the transcriptomic landscape of castration-resistant prostate cancer-associated fibroblasts and their association with prognosis and immunotherapy response

Single-cell sequencing unveils the transcriptomic landscape of castration-resistant prostate cancer-associated fibroblasts and their association with prognosis and immunotherapy response

Abstract Background The tumor microenvironment (TME) is increasingly acknowledged as a determinant in the malignant transformation and progression of castration-resistant prostate cancer (CRPC). Cancer-associated fibroblasts (CAFs), as a pivotal stromal cellular component in TME, are implicated in t...

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Bibliographic Details
Main Authors: Yifeng Qiu, Yuhan Wang, Jiahe Liu, Kai Sun, Baohua Liu, Qi Hou
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Cancer
Subjects:
Castration-resistant prostate cancer
Cancer-associated fibroblasts
Single-cell RNA-sequencing
Clinical outcomes
Immune infiltration
Online Access:https://doi.org/10.1186/s12885-025-14212-x
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https://doi.org/10.1186/s12885-025-14212-x

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