Unveiling fine-scale spatial structures and amplifying gene expression signals in ultra-large ST slices with HERGAST

Abstract We propose HERGAST, a system for spatial structure identification and signal amplification in ultra-large-scale and ultra-high-resolution spatial transcriptomics data. To handle ultra-large spatial transcriptomics (ST) data, we consider the divide and conquer strategy and devise a Divide-It...

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Bibliographic Details
Main Authors: Yuqiao Gong, Xin Yuan, Qiong Jiao, Zhangsheng Yu
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59139-w
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