Towards designing improved cancer immunotherapy targets with a peptide-MHC-I presentation model, HLApollo

Towards designing improved cancer immunotherapy targets with a peptide-MHC-I presentation model, HLApollo

Abstract Based on the success of cancer immunotherapy, personalized cancer vaccines have emerged as a leading oncology treatment. Antigen presentation on MHC class I (MHC-I) is crucial for the adaptive immune response to cancer cells, necessitating highly predictive computational methods to model th...

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Main Authors: William John Thrift, Nicolas W. Lounsbury, Quade Broadwell, Amy Heidersbach, Emily Freund, Yassan Abdolazimi, Qui T. Phung, Jieming Chen, Aude-Hélène Capietto, Ann-Jay Tong, Christopher M. Rose, Craig Blanchette, Jennie R. Lill, Benjamin Haley, Lélia Delamarre, Richard Bourgon, Kai Liu, Suchit Jhunjhunwala
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54887-7
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https://doi.org/10.1038/s41467-024-54887-7

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