Sigma1 inhibitor suppression of adaptive immune resistance mechanisms mediated by cancer cell derived extracellular vesicles

Sigma1 inhibitor suppression of adaptive immune resistance mechanisms mediated by cancer cell derived extracellular vesicles

Adaptive immune resistance in cancer describes the various mechanisms by which tumors adapt to evade anti-tumor immune responses. IFN-γ induction of programmed death-ligand 1 (PD-L1) was the first defined and validated adaptive immune resistance mechanism. The endoplasmic reticulum (ER) is central t...

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Bibliographic Details
Main Authors: Paola A. Castagnino, Derick A. Haas, Luca Musante, Nathalia A. Tancler, Bach V. Tran, Rhonda Kean, Alexandra R. Steck, Luis A. Martinez, Elahe A. Mostaghel, D. Craig Hooper, Felix J. Kim
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Cancer Biology & Therapy
Subjects:
Sigma1/SIGMAR1
extracellular vesicle (EV)
programmed death ligand 1 (PD-L1)
EV-associated PD-L1 (evPD-L1)
Interferon-gamma (ifn-γ)
adaptive immune resistance (AIR)
Online Access:https://www.tandfonline.com/doi/10.1080/15384047.2025.2455722
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https://www.tandfonline.com/doi/10.1080/15384047.2025.2455722

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