Efficacy of probiotic Bacillus licheniformis DSM 28710 on performance and the mitigation of Clostridium perfringens-induced necrotic enteritis in broiler chickens
The aim of this study was to evaluate the impact of a probiotic Bacillus licheniformis strain (DSM 28710; B-Act®) on growth performance and its capacity to mitigate necrotic enteritis (NE; induced via a Clostridium perfringens challenge) in poultry. A broiler trial was conducted, examining three tre...
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Brill
2021-05-01
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| Series: | Journal of Applied Animal Nutrition |
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| Online Access: | https://www.wageningenacademic.com/doi/10.3920/JAAN2020.0013 |
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| author | W. Van der Veken V. Hautekiet E.A. Kimminau C. Hofacre G.F. Mathis |
| author_facet | W. Van der Veken V. Hautekiet E.A. Kimminau C. Hofacre G.F. Mathis |
| author_sort | W. Van der Veken |
| collection | DOAJ |
| description | The aim of this study was to evaluate the impact of a probiotic Bacillus licheniformis strain (DSM 28710; B-Act®) on growth performance and its capacity to mitigate necrotic enteritis (NE; induced via a Clostridium perfringens challenge) in poultry. A broiler trial was conducted, examining three treatments for 42 days under an induced NE challenge; a negative control (basal diet only); an antibiotic treated group (oxytetracycline hydrochloride (OXT), therapeutic dose of 105 mg OXT/litre in drinking water, for three days after C. perfringens challenge); and a B-Act group (500 g B-Act/tonne of feed, equalling 1.6×1012 colony forming units B. licheniformis DSM 28710/tonne of feed, supplemented from start until finish). Despite the induced NE challenge, weight gains of the B-Act and OXT groups were similar to each other but significantly higher compared to the control at the end of the study (P<0.05). Weight gain of the B-Act group was already significantly higher compared to the control on day 21 (P<0.05), indicating a potential benefit of the probiotic even before clinical establishment of NE. Feed conversion ratio (FCR) values followed a similar pattern throughout the study, with a significantly lower overall FCR for the B-Act and OXT groups compared to the control (P<0.05; d0-42). Birds fed B-Act had significantly (P<0.05) lower NE lesions compared to the control and OXT group on day 21, although OXT was not supplemented to the animals at this stage yet. Both B-Act and OXT groups had significantly (P<0.05) lower NE scores than the control on day 28, demonstrating the effectiveness of the antibiotic treatment and the mitigating effect of B-Act on the effects of a Clostridium perfringens induced NE challenge. |
| format | Article |
| id | doaj-art-8828556baea14048827492b835b07735 |
| institution | Kabale University |
| issn | 2049-257X |
| language | English |
| publishDate | 2021-05-01 |
| publisher | Brill |
| record_format | Article |
| series | Journal of Applied Animal Nutrition |
| spelling | doaj-art-8828556baea14048827492b835b077352025-02-03T10:32:21ZengBrillJournal of Applied Animal Nutrition2049-257X2021-05-01911710.3920/JAAN2020.0013Efficacy of probiotic Bacillus licheniformis DSM 28710 on performance and the mitigation of Clostridium perfringens-induced necrotic enteritis in broiler chickensW. Van der Veken0V. Hautekiet1E.A. Kimminau2C. Hofacre3G.F. Mathis4Huvepharma NV, Uitbreidingstraat 80, 2600 Antwerp, Belgium.Huvepharma NV, Uitbreidingstraat 80, 2600 Antwerp, Belgium.Huvepharma Inc., 525 Westpark Drive, Suite 230, Peachtree City, GA 30269, USA.Southern Poultry Research Group, 1061 Hale Road, Watkinsville, GA 30677, USA.Southern Poultry Research Inc., 96 Roquemore Road, Athens, GA 30677, USA.The aim of this study was to evaluate the impact of a probiotic Bacillus licheniformis strain (DSM 28710; B-Act®) on growth performance and its capacity to mitigate necrotic enteritis (NE; induced via a Clostridium perfringens challenge) in poultry. A broiler trial was conducted, examining three treatments for 42 days under an induced NE challenge; a negative control (basal diet only); an antibiotic treated group (oxytetracycline hydrochloride (OXT), therapeutic dose of 105 mg OXT/litre in drinking water, for three days after C. perfringens challenge); and a B-Act group (500 g B-Act/tonne of feed, equalling 1.6×1012 colony forming units B. licheniformis DSM 28710/tonne of feed, supplemented from start until finish). Despite the induced NE challenge, weight gains of the B-Act and OXT groups were similar to each other but significantly higher compared to the control at the end of the study (P<0.05). Weight gain of the B-Act group was already significantly higher compared to the control on day 21 (P<0.05), indicating a potential benefit of the probiotic even before clinical establishment of NE. Feed conversion ratio (FCR) values followed a similar pattern throughout the study, with a significantly lower overall FCR for the B-Act and OXT groups compared to the control (P<0.05; d0-42). Birds fed B-Act had significantly (P<0.05) lower NE lesions compared to the control and OXT group on day 21, although OXT was not supplemented to the animals at this stage yet. Both B-Act and OXT groups had significantly (P<0.05) lower NE scores than the control on day 28, demonstrating the effectiveness of the antibiotic treatment and the mitigating effect of B-Act on the effects of a Clostridium perfringens induced NE challenge.https://www.wageningenacademic.com/doi/10.3920/JAAN2020.0013probioticB-Act®necrotic enteritispoultryperformancegut health |
| spellingShingle | W. Van der Veken V. Hautekiet E.A. Kimminau C. Hofacre G.F. Mathis Efficacy of probiotic Bacillus licheniformis DSM 28710 on performance and the mitigation of Clostridium perfringens-induced necrotic enteritis in broiler chickens Journal of Applied Animal Nutrition probiotic B-Act® necrotic enteritis poultry performance gut health |
| title | Efficacy of probiotic Bacillus licheniformis DSM 28710 on performance and the mitigation of Clostridium perfringens-induced necrotic enteritis in broiler chickens |
| title_full | Efficacy of probiotic Bacillus licheniformis DSM 28710 on performance and the mitigation of Clostridium perfringens-induced necrotic enteritis in broiler chickens |
| title_fullStr | Efficacy of probiotic Bacillus licheniformis DSM 28710 on performance and the mitigation of Clostridium perfringens-induced necrotic enteritis in broiler chickens |
| title_full_unstemmed | Efficacy of probiotic Bacillus licheniformis DSM 28710 on performance and the mitigation of Clostridium perfringens-induced necrotic enteritis in broiler chickens |
| title_short | Efficacy of probiotic Bacillus licheniformis DSM 28710 on performance and the mitigation of Clostridium perfringens-induced necrotic enteritis in broiler chickens |
| title_sort | efficacy of probiotic bacillus licheniformis dsm 28710 on performance and the mitigation of clostridium perfringens induced necrotic enteritis in broiler chickens |
| topic | probiotic B-Act® necrotic enteritis poultry performance gut health |
| url | https://www.wageningenacademic.com/doi/10.3920/JAAN2020.0013 |
| work_keys_str_mv | AT wvanderveken efficacyofprobioticbacilluslicheniformisdsm28710onperformanceandthemitigationofclostridiumperfringensinducednecroticenteritisinbroilerchickens AT vhautekiet efficacyofprobioticbacilluslicheniformisdsm28710onperformanceandthemitigationofclostridiumperfringensinducednecroticenteritisinbroilerchickens AT eakimminau efficacyofprobioticbacilluslicheniformisdsm28710onperformanceandthemitigationofclostridiumperfringensinducednecroticenteritisinbroilerchickens AT chofacre efficacyofprobioticbacilluslicheniformisdsm28710onperformanceandthemitigationofclostridiumperfringensinducednecroticenteritisinbroilerchickens AT gfmathis efficacyofprobioticbacilluslicheniformisdsm28710onperformanceandthemitigationofclostridiumperfringensinducednecroticenteritisinbroilerchickens |