HIV-1 Vif disrupts phosphatase feedback regulation at the kinetochore, leading to a pronounced pseudo-metaphase arrest

HIV-1 Vif disrupts phosphatase feedback regulation at the kinetochore, leading to a pronounced pseudo-metaphase arrest

Virion Infectivity Factor (Vif) of the Human Immunodeficiency Virus type 1 (HIV-1) targets and degrades cellular APOBEC3 proteins, key regulators of intrinsic and innate antiretroviral immune responses, thereby facilitating HIV-1 infection. While Vif’s role in degrading APOBEC3G is well-studied, Vif...

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Bibliographic Details
Main Authors: Dhaval Ghone, Edward L Evans, Madison Bandini, Kaelyn G Stephenson, Nathan M Sherer, Aussie Suzuki
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-03-01
Series:eLife
Subjects:
HIV
cell cycle
mitosis
Vif
Vpr
protein phosphatase
Online Access:https://elifesciences.org/articles/101136
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https://elifesciences.org/articles/101136

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