The cancer-associated fibroblast facilitates YAP liquid-liquid phase separation to promote cancer cell stemness in HCC

The cancer-associated fibroblast facilitates YAP liquid-liquid phase separation to promote cancer cell stemness in HCC

Abstract Cancer stem cells (CSCs) are strongly associated with the refractory characteristics of Hepatocellular carcinoma (HCC). However, the complex interaction between CSCs and the tumor microenvironment remains incompletely understood. In this study, we identified a novel long non-coding RNA (lnc...

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Bibliographic Details
Main Authors: Wei Chen, Yanling Li, Qiaodan Zhou, Wang Peng, Mengdie Cao, Yuchong Zhao, Zihan Yang, Si Xiong, Hai Huang, Luyao Liu, Shuya Bai, Bin Cheng
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cell Communication and Signaling
Subjects:
Hepatocellular carcinoma
Long non-coding RNA
NEAT1
Extracellular vesicle
Liquid-liquid phase separation
Online Access:https://doi.org/10.1186/s12964-025-02256-2
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https://doi.org/10.1186/s12964-025-02256-2

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