Baseline echocardiographic variables as predictors of hemodynamically significant cytokine release syndrome in adults treated with CD19 CAR T-cell therapy for hematological malignancies

Baseline echocardiographic variables as predictors of hemodynamically significant cytokine release syndrome in adults treated with CD19 CAR T-cell therapy for hematological malignancies

Abstract Background CD19 CAR T-cell therapy is a novel anti-cancer treatment that has produced remarkable responses in relapsed or refractory B-cell hematological malignancies. Cytokine Release Syndrome (CRS) is a dysregulated immune response that frequently occurs after CAR T-cell infusion. It can...

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Main Authors: Andres E. Daryanani, Muhannad A. Abbasi, Maria F. Gomez Ardila, Eduardo Tellez-Garcia, Juan M. Garzon-Dangond, Yi Lin, Jonas Paludo, Joerg Herrmann, Stephen M. Ansell, Allison C. Rosenthal, Hector R. Villarraga
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cardio-Oncology
Subjects:
Echocardiography
Chimeric antigen T-cell therapy
B-cell lymphoma
Cytokine release syndrome
Cancer therapy-related cardiac dysfunction
Cardiotoxicity
Online Access:https://doi.org/10.1186/s40959-024-00290-6
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https://doi.org/10.1186/s40959-024-00290-6

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