Correlation between A3243G and G9053A mtDNA mutations and ATP levels in diabetes mellitus patients using qPCR and electrochemical aptasensors

Correlation between A3243G and G9053A mtDNA mutations and ATP levels in diabetes mellitus patients using qPCR and electrochemical aptasensors

Background and purpose: Mitochondrial DNA (mtDNA) mutations can impair oxidative phosphorylation and ATP production, potentially contributing to the pathogenesis of type 2 diabetes mellitus (T2DM). This study aimed to investigate the relationship between mtDNA mutations and ATP levels in blood and...

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Main Authors: Iman Permana Maksum, Rahmaniar Mulyani, Yeni Wahyuni Hartati, Irkham, Fanny Rizki Rahmadanthi, Serly Zuliska, Toto Subroto
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2025-06-01
Series:ADMET and DMPK
Subjects:
Electrochemical biosensor
mitochondrial diabetes diagnostics
mitochondrial mutations
nucleic acid amplification
Online Access:https://pub.iapchem.org/ojs/index.php/admet/article/view/2767
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https://pub.iapchem.org/ojs/index.php/admet/article/view/2767

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