Short-course aminoglycosides as adjunctive treatment in adults with sepsis: A post-hoc analysis of a prematurely terminated cluster randomized trial

Short-course aminoglycosides as adjunctive treatment in adults with sepsis: A post-hoc analysis of a prematurely terminated cluster randomized trial

Background: Cephalosporin monotherapy or cephalosporin-aminoglycoside combination therapy are both used for empirical sepsis treatment in The Netherlands, with no evidence favouring either. We hypothesized that ceftriaxone or cefuroxime monotherapy is non-inferior to cefuroxime combined with gentami...

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Main Authors: Eva L. Koekenbier, Sharon E.J.D. van den Eijnde, Paul D. van der Linden, Jan Jelrik Oosterheert, Elske Sieswerda, Lisanne E.M. Vintcent, Linda M. Kampschreur, Hjalmar R. Bouma, Heidi S.M. Ammerlaan, Michelle Gompelman, Eefje Jong, Jan M. Prins, Anton S.M. Dofferhoff, Marc J.M. Bonten, Cornelis H. van Werkhoven
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:CMI Communications
Subjects:
Cephalosporin
Aminoglycosides
Combination therapy
Community-aquired sepsis
Sepsis
Cluster-randomized
Online Access:http://www.sciencedirect.com/science/article/pii/S2950590925000174
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