Tumor tissue-of-origin classification using miRNA-mRNA-lncRNA interaction networks and machine learning methods

Tumor tissue-of-origin classification using miRNA-mRNA-lncRNA interaction networks and machine learning methods

IntroductionMicroRNAs (miRNAs) regulate gene expression and play an important role in carcinogenesis through complex interactions with messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs). Despite their established influence on tumor progression and therapeutic resistance, the application of mi...

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Bibliographic Details
Main Authors: Ankita Lawarde, Masuma Khatun, Prakash Lingasamy, Andres Salumets, Vijayachitra Modhukur
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Bioinformatics
Subjects:
miRNAs
network
machine learning
feature selection
tumor tissue origin
ensemble learning
Online Access:https://www.frontiersin.org/articles/10.3389/fbinf.2025.1571476/full
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https://www.frontiersin.org/articles/10.3389/fbinf.2025.1571476/full

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