Enhancing sulfasalazine solubility in supercritical carbon dioxide with ethanol cosolvent: a comprehensive study

Enhancing sulfasalazine solubility in supercritical carbon dioxide with ethanol cosolvent: a comprehensive study

Abstract In this study, the solubility of sulfasalazine in supercritical carbon dioxide, using ethanol as a cosolvent, was evaluated at temperatures of 308, 318, 328, and 338 K, and at pressures reaching up to 30 MPa. A comprehensive examination was conducted to ascertain the impact of temperature,...

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Main Authors: Hadil Faris Alotaibi, Suleiman Ibrahim Mohammad, Asokan Vasudevan, Suranjana V. Mayani, Suhas Ballal, Munthar Kadhim Abosaoda, Abhayveer Singh, Subhashree Ray, Atreyi Pramanik
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Sulfasalazine
Solubility
Modeling
Supercritical fluid
Ethanol
Online Access:https://doi.org/10.1038/s41598-025-04232-9
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https://doi.org/10.1038/s41598-025-04232-9

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