Exon junction complexes regulate osteoclast‐induced bone resorption by influencing the NFATc1 m6A distribution through the “shield effect”

Exon junction complexes regulate osteoclast‐induced bone resorption by influencing the NFATc1 m6A distribution through the “shield effect”

Abstract Background The distribution of the m6A methylation modification on the transcriptome is highly regionally selective and is mainly concentrated in abnormally long exons and stop codons. However, in‐depth research on the selective mechanism of m6A methylation is still lacking. Methods In this...

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Bibliographic Details
Main Authors: Bao Sun, Jin‐Gang Yang, Zhe Wang, Zheng Wang, Wei Feng, Xing Li, Sheng‐Nan Liu, Jiang Li, Ya‐Qin Zhu, Ping Zhang, Wei Wang
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Clinical and Translational Medicine
Subjects:
exon junction complexes
m6A distribution characteristics
osteoclast
osteoporosis
shield effect
Online Access:https://doi.org/10.1002/ctm2.70266
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https://doi.org/10.1002/ctm2.70266

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