Development of an adipocyte differentiation protocol using 3T3-L1 cells for the investigation of the browning process: identification of the PPAR-γ agonist rosiglitazone as a browning reference drug

Development of an adipocyte differentiation protocol using 3T3-L1 cells for the investigation of the browning process: identification of the PPAR-γ agonist rosiglitazone as a browning reference drug

BackgroundObesity is a metabolic disease that is characterized by an excessive accumulation of adipose tissue (AT) and is often associated with other pathologies. AT is a lipid storage organ with endocrine functions that presents two main phenotypes: white adipose tissue (WAT) and brown adipose tiss...

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Bibliographic Details
Main Authors: Lorenzo Flori, Giulia Galgani, Giorgia Bray, Chiara Ippolito, Cristina Segnani, Carolina Pellegrini, Valentina Citi, Nunzia Bernardini, Alma Martelli, Vincenzo Calderone
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
browning
beige adipocyte
white adipocyte
adipocyte differentiation
3T3-L1
PPAR-γ
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1546456/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1546456/full

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