The green tea component (−)-epigallocatechin-3-gallate protects against cytokine-induced epithelial barrier damage in intestinal epithelial cells

The green tea component (−)-epigallocatechin-3-gallate protects against cytokine-induced epithelial barrier damage in intestinal epithelial cells

BackgroundGreen tea consumption is associated with health benefits, which are mainly attributed to its catechins, especially the main catechin (−)-epigallocatechin-3-gallate (EGCG). Among other beneficial effects, EGCG was shown to be protective in inflammatory bowel disease (IBD), a condition assoc...

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Bibliographic Details
Main Authors: Rita Rosenthal, Anne Waesch, Kopano Valerie Masete, Alain S. Massarani, Jörg-Dieter Schulzke, Nina A. Hering
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
(−)-epigallocatechin-3-gallate
TNFα
IFNγ
epithelial barrier breakdown
apoptosis
macromolecular flux
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1559812/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1559812/full

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