Single-cell sequencing reveals dysregulated cell type perturbations and critical mediator communication remodelling in colorectal cancer

Single-cell sequencing reveals dysregulated cell type perturbations and critical mediator communication remodelling in colorectal cancer

BackgroundThe heterogeneity of colorectal cancer (CRC) and its complex immune microenvironment pose significant challenges for treatment. Understanding the cellular composition and dynamic changes is essential for uncovering mechanisms of tumour progression.MethodsTo investigate the cellular heterog...

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Bibliographic Details
Main Authors: Chengyuan Xu, Siqi Zhang, Zhouyu Zhang, Luoqiu Zhang, Bin Sun, Zicheng Yu, Hailong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
single-cell sequencing
colorectal cancer
tumour microenvironment
cellular heterogeneity
immune regulation
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Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557564/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557564/full

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