Quantification of neuroinflammation in spinal cord and neuroforamina of patients with painful cervical radiculopathy using [11C]DPA713 PET/CT

Quantification of neuroinflammation in spinal cord and neuroforamina of patients with painful cervical radiculopathy using [11C]DPA713 PET/CT

BackgroundAnimal models of nerve compression have revealed neuroinflammation not only at the entrapment site, but also remotely at the spinal cord. However, there is limited information on the presence of neuroinflammation in human compression neuropathies. The objectives of this study were to: (1)...

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Main Authors: Ivo J. Lutke Schipholt, Gwendolyne G. M. Scholten-Peeters, Meghan A. Koop, Michel W. Coppieters, Ronald Boellaard, Elsmarieke van de Giessen, Bastiaan C. ter Meulen, Marieke Coenen, Carmen Vleggeert-Lankamp, Paul R. Depaauw, Bart N. M. van Berckel, Adriaan A. Lammerstma, Maqsood Yaqub
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Nuclear Medicine
Subjects:
neuroinflammation
neuropathic pain
PET imaging
cervical radiculopathy
immunoactivation
PET quantification data collection
Online Access:https://www.frontiersin.org/articles/10.3389/fnume.2025.1569991/full
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https://www.frontiersin.org/articles/10.3389/fnume.2025.1569991/full

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