Intestinal Fut2 deficiency exacerbated alcohol‐related liver disease by disrupting nicotinamide metabolism

Intestinal Fut2 deficiency exacerbated alcohol‐related liver disease by disrupting nicotinamide metabolism

Abstract Background Fucosyltransferase 2 (FUT2)‐dependent fucosylation of intestinal epithelial cells is vital for preserving gut barrier integrity and microbial balance. Nevertheless, its precise involvement in alcohol‐associated liver disease has yet to be fully elucidated. Methods We generated mi...

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Bibliographic Details
Main Authors: Liuying Chen, Zhongwei Yin, Luorui Shang, Hang Yuan, Wenkang Gao, Shuhan Wang, Shuyan Wang, Xiaohua Hou, Shenglan Yang, Huikuan Chu
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Clinical and Translational Medicine
Subjects:
alcohol‐related liver disease
fucosyltransferase 2
NAD
nicotinamidase
Online Access:https://doi.org/10.1002/ctm2.70447
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https://doi.org/10.1002/ctm2.70447

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