Distinctive biochemical properties of the μ-opioid receptor-corticotropin- releasing factor CRF1 receptor heterotetramer

Distinctive biochemical properties of the μ-opioid receptor-corticotropin- releasing factor CRF1 receptor heterotetramer

Heteromerization of Gs with Gi protein-coupled receptors has been suggested to be necessary to sustain the canonical Gi-Gs antagonistic interaction at adenylyl cyclase (AC). These heteromers have a tetrameric quaternary structure, composed by two homodimers each one coupled to its corresponding G pr...

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Bibliographic Details
Main Authors: William N. Sanchez, Estefanía Moreno, Marc Ciruela-Jardí, Nil Casajuana-Martín, Anne Yauch, Ning-Sheng Cai, Cesar Quiroz, Ya Gin Chang, Vicent Casadó, Leonardo Pardo, Leigh D. Plant, Sergi Ferré
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Pharmacological Research
Subjects:
μ-opioid receptor
CRF1 receptor
Heteromers
Phospholipase C
Calcium signaling
Central amygdala
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825003299
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