Unveiling an Arpp-19 phosphorylation switch that grants chromosome stability
Abstract During cell division, the onset of mitosis is granted by activation of cyclin B-dependent kinase 1 (Cdk1), master mitotic kinase, coordinated with inactivation of Cdk1-counteracting phosphatases. PP2A-B55, a major of these phosphatases, is inhibited in mitosis by Arpp-19 and Ensa, two very...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-08281-8 |
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