Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs
Abstract This study aimed to investigate the in vitro performance of self-nanoemulsifying drug delivery systems (SNEDDSs) of Ornidazole (ORD), a poorly water-soluble drug. Self-nanoemulsifying drug delivery systems of ORD were prepared using various oils, non-ionic surfactants, and/or water-soluble...
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Nature Portfolio
2024-11-01
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| Online Access: | https://doi.org/10.1038/s41598-024-73760-7 |
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| author | Popat Mohite Shruti Sule Anil Pawar Hanan M. Alharbi Swastika Maitra Vetriselvan Subramaniyan Vinoth Kumarasamy Daniel Ejim Uti Celestine O. Ogbu Simon Inedu Oodo Ajoy Kumer Ayodeji Oluwafemi Idowu Okechukwu N. N. Okoye |
| author_facet | Popat Mohite Shruti Sule Anil Pawar Hanan M. Alharbi Swastika Maitra Vetriselvan Subramaniyan Vinoth Kumarasamy Daniel Ejim Uti Celestine O. Ogbu Simon Inedu Oodo Ajoy Kumer Ayodeji Oluwafemi Idowu Okechukwu N. N. Okoye |
| author_sort | Popat Mohite |
| collection | DOAJ |
| description | Abstract This study aimed to investigate the in vitro performance of self-nanoemulsifying drug delivery systems (SNEDDSs) of Ornidazole (ORD), a poorly water-soluble drug. Self-nanoemulsifying drug delivery systems of ORD were prepared using various oils, non-ionic surfactants, and/or water-soluble co-solvents and assessed visually/by droplet size measurement. Equilibrium solubility of ORD in the anhydrous and diluted SNEDDS was conducted to achieve the maximum drug loading. The in vitro dissolution of SNEDDS was studied to compare the solubility of the representative formulations with API. The results from the characterization and solubility studies showed that SNEDDS formulations were stable with lower droplet sizes and showed higher ORD solubility. From the dissolution studies, it was found that the developed A7-SNEDDS formulation provided a significantly higher rate of ORD release (98.94 ± 0.68 in 1.0 h) compared to API. ORD-loaded SNEDDS formulations could be a potential oral pharmaceutical product with high drug-loading capacity, improved drug dissolution, and enhanced oral bioavailability. |
| format | Article |
| id | doaj-art-8752ff4a2b764cbe92d85b826c54aaff |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-8752ff4a2b764cbe92d85b826c54aaff2025-08-20T03:18:32ZengNature PortfolioScientific Reports2045-23222024-11-0114111810.1038/s41598-024-73760-7Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugsPopat Mohite0Shruti Sule1Anil Pawar2Hanan M. Alharbi3Swastika Maitra4Vetriselvan Subramaniyan5Vinoth Kumarasamy6Daniel Ejim Uti7Celestine O. Ogbu8Simon Inedu Oodo9Ajoy Kumer10Ayodeji Oluwafemi Idowu11Okechukwu N. N. Okoye12AETs St. John Institute of Pharmacy and ResearchMES’s College of PharmacyMES’s College of PharmacyDepartment of Pharmaceutical Sciences, College of Pharmacy, Umm Al-Qura UniversityCenter for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical SciencesDepartment of Genetics and Development, Columbia University Irving Medical CenterDepartment of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan MalaysiaDepartment of Research Publications, Kampala International UniversityDepartment of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Federal University of Health SciencesDepartment of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Federal University of Health SciencesChemistry, IUBAT-International University of Business Agriculture & TechnologyCentre for Excellence in Functional foods and Gastronomy Faculty of Agro-industry, Prince of Songkla UniversityDepartment of Industrial Chemistry, College of Science, Evangel University AkaezeAbstract This study aimed to investigate the in vitro performance of self-nanoemulsifying drug delivery systems (SNEDDSs) of Ornidazole (ORD), a poorly water-soluble drug. Self-nanoemulsifying drug delivery systems of ORD were prepared using various oils, non-ionic surfactants, and/or water-soluble co-solvents and assessed visually/by droplet size measurement. Equilibrium solubility of ORD in the anhydrous and diluted SNEDDS was conducted to achieve the maximum drug loading. The in vitro dissolution of SNEDDS was studied to compare the solubility of the representative formulations with API. The results from the characterization and solubility studies showed that SNEDDS formulations were stable with lower droplet sizes and showed higher ORD solubility. From the dissolution studies, it was found that the developed A7-SNEDDS formulation provided a significantly higher rate of ORD release (98.94 ± 0.68 in 1.0 h) compared to API. ORD-loaded SNEDDS formulations could be a potential oral pharmaceutical product with high drug-loading capacity, improved drug dissolution, and enhanced oral bioavailability.https://doi.org/10.1038/s41598-024-73760-7Ornidazole self-nano emulsifying systemSurfactantCosurfactant, solubility |
| spellingShingle | Popat Mohite Shruti Sule Anil Pawar Hanan M. Alharbi Swastika Maitra Vetriselvan Subramaniyan Vinoth Kumarasamy Daniel Ejim Uti Celestine O. Ogbu Simon Inedu Oodo Ajoy Kumer Ayodeji Oluwafemi Idowu Okechukwu N. N. Okoye Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs Scientific Reports Ornidazole self-nano emulsifying system Surfactant Cosurfactant, solubility |
| title | Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs |
| title_full | Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs |
| title_fullStr | Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs |
| title_full_unstemmed | Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs |
| title_short | Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs |
| title_sort | development and characterization of a self nano emulsifying drug delivery system snedds for ornidazole to improve solubility and oral bioavailability of bcs class ii drugs |
| topic | Ornidazole self-nano emulsifying system Surfactant Cosurfactant, solubility |
| url | https://doi.org/10.1038/s41598-024-73760-7 |
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