Comparative efficacy, toxicity, and insulin-suppressive effects of simvastatin and pravastatin in fatty acid-challenged mouse insulinoma MIN6 β-cell model

Comparative efficacy, toxicity, and insulin-suppressive effects of simvastatin and pravastatin in fatty acid-challenged mouse insulinoma MIN6 β-cell model

IntroductionFamilial hypercholesterolemia, the highly prevalent form of dyslipidemia, is a well-known risk factor for premature heart disease and stroke worldwide. Statins, which inhibit 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase, are the first-choice treatment for dyslipidemias, and...

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Main Authors: Hossein Arefanian, Sardar Sindhu, Fatema Al-Rashed, Fawaz Alzaid, Ashraf Al Madhoun, Mohammed Qaddoumi, Fatemah Bahman, Michayla R. Williams, Shaima Albeloushi, Nourah Almansour, Rasheed Ahmad, Fahd Al-Mulla
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Endocrinology
Subjects:
pancreatic β-cells
MIN6 cells
statin
simvastatin
pravastatin
mitochondrial respiration
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1383448/full
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https://www.frontiersin.org/articles/10.3389/fendo.2024.1383448/full

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