PCM1 orchestrates centrosomal and flagellar protein transport to promote sperm maturation

PCM1 orchestrates centrosomal and flagellar protein transport to promote sperm maturation

Abstract Centriolar satellites facilitate the delivery of proteins required for centrosome assembly and function, and rely on the nucleation of the scaffold protein pericentriolar material 1 (PCM1). During sperm maturation, centrosomes undergo remodeling to facilitate neckpiece formation and flagell...

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Main Authors: Zicong Huang, Runduan Yi, Xixian Cen, Hanbin Zhang, Minyu Xie, Ke Ma, Shipeng Ruan, Yuge Zhuang, Xiaoyuan Zhang, Wenyuan Liu, Hongrui Feng, Deyu Chen, Mohamed Morsi M. Ahmed, Hong Liu, Chuyu Huang, Xiangjin Kang, Zhenguo Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08319-x
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https://doi.org/10.1038/s42003-025-08319-x

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