AliC and AliD of nonencapsulated Streptococcus pneumoniae enhance virulence in a Galleria mellonella model of infection by contributing to reactive oxygen species resistance

AliC and AliD of nonencapsulated Streptococcus pneumoniae enhance virulence in a Galleria mellonella model of infection by contributing to reactive oxygen species resistance

IntroductionNonencapsulated Streptococcus pneumoniae (NESp) are isolated worldwide. Due to the lack of capsule in NESp strains the current vaccines, that target the pneumococcal capsule are ineffective. Some NESp contain the oligopeptide transporters AliC and AliD which are required for virulence th...

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Bibliographic Details
Main Authors: Courtney D. Thompson, Md Fahim Khan, Lucas R. G. Crosby, Shelby G. Holcomb, Ana G. Jop Vidal, Jorge E. Vidal, Larry S. McDaniel, Lance E. Keller
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Streptococcus pneumoniae
oligopeptide transporter
Galleria mellonella
virulence factor
host-pathogen
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1583375/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1583375/full

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