Development of a Recombinant Fusion Vaccine Candidate Against Lethal <i>Clostridium botulinum</i> Neurotoxin Types A and B

Development of a Recombinant Fusion Vaccine Candidate Against Lethal <i>Clostridium botulinum</i> Neurotoxin Types A and B

Background: Botulinum neurotoxins (BoNTs), produced by <i>Clostridium botulinum</i>, are potent protein toxins that can cause botulism, which leads to death or neuroparalysis in humans by targeting the nervous system. BoNTs comprise three functional domains: a light-chain enzymatic domai...

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Bibliographic Details
Main Authors: Eun-Sun Choi, Seong-Wook Pyo, So-Hyeon Kim, Jun-Ho Jeon, Gi-Eun Rhie, Mi-Ran Yun, Hwajung Yi, Yoon-Seok Chung
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Vaccines
Subjects:
<i>Clostridium botulinum</i>
botulism
neurotoxin
fusion vaccine
receptor binding domain
Online Access:https://www.mdpi.com/2076-393X/13/1/39
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