A cautionary note on the potential pitfalls of using N-terminal truncated CD63 to label small extracellular vesicles

Abstract Small extracellular vesicles (sEV) are nanosized vesicles that facilitate intracellular communication. A significant research obstacle is the isolation of sEV devoid of non-sEV contaminants. Immunoaffinity capture with sEV-specific antibodies is an attractive approach to purifying sEV, but...

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Bibliographic Details
Main Authors: Elias Sulaiman, Derek M. Yellon, Sean M. Davidson
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-91597-6
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