Revealing the Improving Effect and Molecular Mechanism of <i>L</i>-Clausenamide in Combating the Acute Lung Injury: Insights from Network Pharmacology, Molecular Docking, and In Vitro Validation

Revealing the Improving Effect and Molecular Mechanism of <i>L</i>-Clausenamide in Combating the Acute Lung Injury: Insights from Network Pharmacology, Molecular Docking, and In Vitro Validation

Acute lung injury is a severe disease with a high mortality rate, which can result in increased oxidative stress and further mitochondrial damage and cell apoptosis. <i>L</i>-Clausenamide is an amide from the fruit wampee. This study combined network pharmacology, molecular docking, and...

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Bibliographic Details
Main Authors: Yu Fu, Nannan Wang, Jinhai Luo, Yanyi Huang, Baoning Liu, Charles S. Brennan, Baojun Xu, Jincan Luo
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biology
Subjects:
<i>L</i>-Clausenamide
acute lung injury
ROS
apoptosis
<i>Clausena lansium</i>
Online Access:https://www.mdpi.com/2079-7737/14/7/836
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https://www.mdpi.com/2079-7737/14/7/836

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